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・ Glycoside hydrolase family 11
・ Glycoside hydrolase family 12
・ Glycoside hydrolase family 13
・ Glycoside hydrolase family 14
・ Glycoside hydrolase family 15
・ Glycoside hydrolase family 16
・ Glycoside hydrolase family 17
・ Glycoside hydrolase family 18
・ Glycoside hydrolase family 19
・ Glycoside hydrolase family 2
・ Glycoside hydrolase family 20
・ Glycoside hydrolase family 22
・ Glycoside hydrolase family 24
・ Glycoside hydrolase family 25
・ Glycoside hydrolase family 26
Glycoside hydrolase family 27
・ Glycoside hydrolase family 28
・ Glycoside hydrolase family 29
・ Glycoside hydrolase family 3
・ Glycoside hydrolase family 30
・ Glycoside hydrolase family 31
・ Glycoside hydrolase family 32
・ Glycoside hydrolase family 33
・ Glycoside hydrolase family 34
・ Glycoside hydrolase family 35
・ Glycoside hydrolase family 36
・ Glycoside hydrolase family 37
・ Glycoside hydrolase family 38
・ Glycoside hydrolase family 39
・ Glycoside hydrolase family 4


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Glycoside hydrolase family 27 : ウィキペディア英語版
Glycoside hydrolase family 27

In molecular biology, glycoside hydrolase family 27 is a family of glycoside hydrolases.
Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.〔(Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999. )〕 This classification is available on the CAZy (http://www.cazy.org) web site,〔(Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999. )〕 and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.〔(CAZypedia, an online encyclopedia of carbohydrate-active enzymes. )〕
Glycoside hydrolase family 27 together with family 31 and the family 36 alpha-galactosidases form the glycosyl hydrolase clan GH-D ((CAZY GH )), a superfamily of alpha-galactosidases, alpha-N-acetylgalactosaminidases, and isomaltodextranases which are likely to share a common catalytic mechanism and structural topology.
Alpha-galactosidase () (melibiase) catalyzes the hydrolysis of melibiose into galactose and glucose. In man, the deficiency of this enzyme is the cause of Fabry's disease (X-linked sphingolipidosis). Alpha-galactosidase is present in a variety of organisms. There is a considerable degree of similarity in the sequence of alpha-galactosidase from various eukaryotic species. ''Escherichia coli'' alpha-galactosidase (gene melA), which requires NAD and magnesium as cofactors, is not structurally related to the eukaryotic enzymes; by contrast, an ''Escherichia coli'' plasmid encoded alpha-galactosidase (gene rafA ) contains a region of about 50 amino acids which is similar to a domain of the eukaryotic alpha-galactosidases. Alpha-N-acetylgalactosaminidase () catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D- galactosaminides. In man, the deficiency of this enzyme is the cause of Schindler and Kanzaki diseases. The sequence of this enzyme is highly related to that of the eukaryotic alpha-galactosidases.
==References==


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